[D-丙氨酸2，D-亮氨酸5]脑啡肽对甲基苯丙胺所致多巴胺转运体丧失的逆转作用。

Reversal by [D-Ala2,D-Leu5]enkephalin of the dopamine transporter loss caused by methamphetamine.

作者信息

Tsao L I, Cadet J L, Su T P

机构信息

Molecular Neuropsychiatry Section, Intramural Research Program, National Institute on Drug Abuse/ NIH, Baltimore, MD 21224, USA.

出版信息

Eur J Pharmacol. 1999 May 21;372(3):R5-7. doi: 10.1016/s0014-2999(99)00240-x.

DOI:10.1016/s0014-2999(99)00240-x

PMID:10395030

Abstract

A single administration of 40 mg/kg (i.p.) of methamphetamine caused a loss of dopamine transporter in the striatum of albino Swiss (CD-1) mouse for at least 3 weeks. The administration of a single dose of [D-Ala2,D-Leu5]enkephalin (DADLE) (18 mg/kg, i.p.), given at day 14 after the administration of methamphetamine, caused a significant, transient restoration of dopamine transporter level in the striatum. These results suggest that delta-opioid peptide DADLE is able to reverse the neuronal damage caused by methamphetamine.

摘要

腹腔注射40毫克/千克甲基苯丙胺一次，可导致白化瑞士（CD - 1）小鼠纹状体中的多巴胺转运体缺失至少3周。在甲基苯丙胺给药后第14天腹腔注射单剂量的[D - Ala2，D - Leu5]脑啡肽（DADLE）（18毫克/千克），可使纹状体中的多巴胺转运体水平显著且短暂地恢复。这些结果表明，δ-阿片肽DADLE能够逆转甲基苯丙胺造成的神经元损伤。