Department of Neurosurgery and Brain Repair, University of South Florida College of Medicine, Tampa, FL 33612, USA.
Int J Mol Sci. 2013 Aug 23;14(9):17410-9. doi: 10.3390/ijms140917410.
In pursuit of neurological therapies, the opioid system, specifically delta opioid receptors and delta opioid peptides, demonstrates promising therapeutic potential for stroke, Parkinson's disease, and other degenerative neurological conditions. Recent studies offer strong evidence in support of the therapeutic use of delta opioid receptors, and provide insights into the underlying mechanisms of action. Delta opioid receptors have been shown to confer protective effects by mediating ionic homeostasis and activating endogenous neuroprotective pathways. Additionally, delta opioid agonists such as (D-Ala 2, D-Leu 5) enkephalin (DADLE) have been shown to decrease apoptosis and promote neuronal survival. In its entirety, the delta opioid system represents a promising target for neural therapies.
为了寻求神经治疗方法，阿片系统，特别是δ阿片受体和 δ 阿片肽，在中风、帕金森病和其他神经退行性疾病方面显示出有希望的治疗潜力。最近的研究为 δ 阿片受体的治疗用途提供了强有力的证据，并深入了解其作用机制。δ 阿片受体通过调节离子动态平衡和激活内源性神经保护途径，发挥保护作用。此外，δ 阿片激动剂，如(D-Ala 2, D-Leu 5)脑啡肽(DADLE)，已被证明可减少细胞凋亡并促进神经元存活。总的来说，δ 阿片系统是神经治疗的一个很有前途的靶点。
