Gottfredsson M, Cox G M, Indridason O S, de Almeida G M, Heald A E, Perfect J R
Department of Medicine, Division of Infectious Diseases and International Health and Nephrology, Duke University Medical Center, Durham, NC 27710, USA.
J Infect Dis. 1999 Aug;180(2):534-7. doi: 10.1086/314887.
The pathophysiology of oropharyngeal candidiasis in patients infected with human immunodeficiency virus (HIV) type 1 is poorly understood. Association between oropharyngeal yeast carriage and various clinical factors in HIV-1-infected patients was studied in 83 patients with no clinical evidence of thrush and no recent antifungal use. Of the clinical factors measured, the only correlate of yeast colonization was with plasma HIV-1 RNA levels (P=.001), whereas the correlation with CD4 cell count was poor (P=.36). By multivariable regression modeling, plasma HIV-1 RNA was the only parameter that correlated with the extent of colonization with Candida infection (P=.003). These data indicate that the presence and amount of asymptomatic oropharyngeal yeast carriage in persons with HIV-1 infection is more significantly correlated with plasma HIV-1 RNA levels than with CD4 cell count. Further studies on the effect of HIV-1 on oropharyngeal yeast colonization, infection, and local immunity are warranted.
1型人类免疫缺陷病毒（HIV）感染患者口腔念珠菌病的病理生理学仍未完全明确。在83例无鹅口疮临床证据且近期未使用抗真菌药物的HIV-1感染患者中，研究了口腔酵母菌携带与各种临床因素之间的关联。在所测量的临床因素中，酵母菌定植的唯一相关因素是血浆HIV-1 RNA水平（P = 0.001），而与CD4细胞计数的相关性较差（P = 0.36）。通过多变量回归模型分析，血浆HIV-1 RNA是与念珠菌感染定植程度相关的唯一参数（P = 0.003）。这些数据表明，HIV-1感染者无症状口腔酵母菌携带的存在和数量与血浆HIV-1 RNA水平的相关性比与CD4细胞计数的相关性更显著。有必要进一步研究HIV-1对口腔酵母菌定植、感染和局部免疫的影响。
