Hrelia S, Pession A, Buda R, Lorenzini A, Horrobin D F, Biagi P L, Bordoni A
Department of Biochemistry G. Moruzzi, University of Bologna, Italy.
Prostaglandins Leukot Essent Fatty Acids. 1999 Apr;60(4):235-41. doi: 10.1054/plef.1999.0030.
Gamma-linolenic acid (GLA) supplemented to neuroblastoma SK-N-BE, tubal carcinoma TG and colon carcinoma SW-620 cells was incorporated into phospholipids in all the cell lines (although to different extents), in a concentration- and time-dependent manner. All the cell lines were able to metabolize GLA to arachidonic acid, SK-N-BE being the most active. Supplementation with low GLA concentrations for short periods was not sufficient to impair cell proliferation; only higher amounts of GLA had an anti-proliferative effect also in short times. In these conditions, the antiproliferative effect of GLA is probably due to cellular dysfunction caused by fatty acid modifications.
添加到神经母细胞瘤SK-N-BE、输卵管癌TG和结肠癌SW-620细胞中的γ-亚麻酸（GLA）以浓度和时间依赖性方式被整合到所有细胞系的磷脂中（尽管程度不同）。所有细胞系都能够将GLA代谢为花生四烯酸，其中SK-N-BE最为活跃。短时间内补充低浓度的GLA不足以损害细胞增殖；只有较高剂量的GLA在短时间内也具有抗增殖作用。在这些条件下，GLA的抗增殖作用可能是由于脂肪酸修饰引起的细胞功能障碍。
