原发性中枢神经系统淋巴瘤患者脑脊液中可溶性CD27水平升高。
Increased levels of CSF soluble CD27 in patients with primary central nervous system lymphoma.
作者信息
Murase S, Saio M, Takenaka K, Shinoda J, Nishimura Y, Sakai N, Takami T
机构信息
Department of Neurosurgery, Gifu University School of Medicine, Japan.
出版信息
Cancer Lett. 1998 Oct 23;132(1-2):181-6. doi: 10.1016/s0304-3835(98)00181-5.
The aim of this study is to determine the diagnostic value of cerebrospinal fluid (CSF) soluble CD27 (sCD27) as a tumor marker for primary central nervous system lymphoma (PCNSL). We examined sCD27 levels in CSF obtained from various types of brain tumor patients. Forty-two patients were studied (including 12 PCNSL patients) who had not received any therapy for their tumors. In all PCNSL cases, CSF sCD27 levels were more than 15 U/ml (median 84.5 U/ml, range 17-484 U/ml) and in other brain tumor cases, CSF sCD27 levels were all less than 15 U/ml. Our data suggest that CSF sCD27 levels are useful to distinguish PCNSL from other brain tumors.
本研究的目的是确定脑脊液（CSF）可溶性CD27（sCD27）作为原发性中枢神经系统淋巴瘤（PCNSL）肿瘤标志物的诊断价值。我们检测了各类脑肿瘤患者脑脊液中的sCD27水平。对42例未接受过任何肿瘤治疗的患者进行了研究（包括12例PCNSL患者）。在所有PCNSL病例中，脑脊液sCD27水平均高于15 U/ml（中位数84.5 U/ml，范围17 - 484 U/ml），而在其他脑肿瘤病例中，脑脊液sCD27水平均低于15 U/ml。我们的数据表明，脑脊液sCD27水平有助于区分PCNSL与其他脑肿瘤。
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