20(S)-喜树碱的新型C环类似物-第2部分：5-C-取代的20(S)-喜树碱类似物的合成及体外细胞毒性
Novel C-ring analogues of 20(S)-camptothecin-part-2: synthesis and in vitro cytotoxicity of 5-C-substituted 20(S)-camptothecin analogues.
作者信息
Subrahmanyam D, Venkateswarlu A, Venkateswara Rao K, Sastry T V, Vandana G, Kumar S A
机构信息
Natural Products Division, Dr. Reddy's Research Foundation, Miyapur, Hyderabad, India.
出版信息
Bioorg Med Chem Lett. 1999 Jun 21;9(12):1633-8. doi: 10.1016/s0960-894x(99)00268-1.
Abstract
A series of 5-C-substituted 20(S)-camptothecin analogues were synthesised and evaluated their in vitro anti-cancer activity. Several of these analogues have showed excellent activity against human tumor cell lines.
摘要
合成了一系列5-C-取代的20(S)-喜树碱类似物，并评估了它们的体外抗癌活性。其中几种类似物对人肿瘤细胞系表现出优异的活性。
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