[类风湿关节炎中的可溶性黏附分子（P-选择素、细胞间黏附分子-1和细胞间黏附分子-3）]
[Soluble adhesion molecules (P-selectin, ICAM-1 and ICAM-3) in rheumatoid arthritis].
作者信息
Nasonov E L, Samsonov M Iu, Tilz G P, Nikiforova E L, Chichasova N V, Imametdinova G R, Ilich-Stoianovich O, Baranov A A, Fuchs D, Nasonova V A
出版信息
Ter Arkh. 1999;71(5):17-20.
AIM
Investigation of serum levels and clinical role of soluble intercellular molecules of adhesion (pICAM-1, PICAM-3 and pP-selectin) in rheumatoid arthritis (RA).
MATERIALS AND METHODS
Enzyme immunoassay with Bender MedSystem kits (Austria) was employed to measure serum concentration of soluble intercellular molecules of adhesion in 36 RA patients.
RESULTS
Elevated levels of serum pICAM-1, pICAM-3 and pP-selectin were registered in 74.2, 28.6 and 25.7% of RA patients, respectively. Content of pP-selectin more strongly correlated with activity and severity indices than that of pICAM-3 (p < 0.001). Content of pICAM-1 and clinical picture of RA were unrelated.
CONCLUSION
Levels of pP-selectine can characterize RA activity.
目的
研究类风湿关节炎（RA）患者血清中可溶性细胞间黏附分子（pICAM-1、PICAM-3和pP-选择素）的水平及其临床作用。
材料与方法
采用奥地利Bender MedSystem试剂盒进行酶免疫测定，检测36例RA患者血清中可溶性细胞间黏附分子的浓度。
结果
分别有74.2%、28.6%和25.7%的RA患者血清pICAM-1、pICAM-3和pP-选择素水平升高。与pICAM-3相比，pP-选择素的含量与活动度和严重程度指标的相关性更强（p<0.001）。pICAM-1的含量与RA的临床表现无关。
结论
pP-选择素水平可表征RA的活动度。
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