Nasonov E L, Samsonov M Iu, Tilz G P, Nikiforova E L, Chichasova N V, Imametdinova G R, Ilich-Stoianovich O, Baranov A A, Fuchs D, Nasonova V A
Ter Arkh. 1999;71(5):17-20.
Investigation of serum levels and clinical role of soluble intercellular molecules of adhesion (pICAM-1, PICAM-3 and pP-selectin) in rheumatoid arthritis (RA).
Enzyme immunoassay with Bender MedSystem kits (Austria) was employed to measure serum concentration of soluble intercellular molecules of adhesion in 36 RA patients.
Elevated levels of serum pICAM-1, pICAM-3 and pP-selectin were registered in 74.2, 28.6 and 25.7% of RA patients, respectively. Content of pP-selectin more strongly correlated with activity and severity indices than that of pICAM-3 (p < 0.001). Content of pICAM-1 and clinical picture of RA were unrelated.
Levels of pP-selectine can characterize RA activity.
研究类风湿关节炎（RA）患者血清中可溶性细胞间黏附分子（pICAM-1、PICAM-3和pP-选择素）的水平及其临床作用。
采用奥地利Bender MedSystem试剂盒进行酶免疫测定，检测36例RA患者血清中可溶性细胞间黏附分子的浓度。
分别有74.2%、28.6%和25.7%的RA患者血清pICAM-1、pICAM-3和pP-选择素水平升高。与pICAM-3相比，pP-选择素的含量与活动度和严重程度指标的相关性更强（p<0.001）。pICAM-1的含量与RA的临床表现无关。
pP-选择素水平可表征RA的活动度。
