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[考虑不同活力状态下新生犊牛出生后最初几天的酸碱状态]

[Acid-base status in newborn calves during the first days of life considering different states of vitality].

作者信息

Herfen K, Bostedt H

机构信息

Klinik für Geburtshilfe, Gynäkologie und Andrologie der Gross- und Kleintiere mit Tierärztlicher Ambulanz, Justus-Liebig-Universität Giessen.

出版信息

Berl Munch Tierarztl Wochenschr. 1999 Jun;112(5):166-71.

PMID:10399402
Abstract

The aim of this study is to describe the differentiations of the acid-base status in bovine neonates during the first 96 hours of life. Due to the short intervals in the taking of blood samples, noticeable fluctuations in the acid-base status during the first minutes and hours of life of newborn calves were documented. Altogether, 25 matures and eutrophe calves of the DSB, DRB and DFV breeds were provided by the clinic for this study. Apart from an immediate post natum clinical interpretation of the vital signs in the neonates-using the APGAR-score-the pH value, current Base Excess and the CO2 pressure were simultaneously ascertained. Further continuous evaluation of the acid-base status was subsequently followed in the first phase of adaptation. For that alone, twelve blood samples were taken from the vena jugularis within the first 60 minutes after parturition. Until the end of the examination period on the fourth day of life, the tests amounted to 26 measurements altogether per experimentee. Due to the concrete results ascertained from the initial clinical and laboratory observations, the experimentees could be divided into distinct classes of vitality. The acid-base status of all the calves deteriorated during the first minutes of life, indicating that the pH value and Base Excess fall clearly under the initial level in all aspects of vitality directly post natum. On average the minimum pH values are reached between the third and 15th minute of life and remain between 0.019 and 0.096 below the initial values during this period. A varying rapid increase of the pH value follows, together with a balancing out of the Base difference. Despite isolated individual variations as the acid-base status develops, the lowering of the pH values in the first minutes of life is assessed as being a normal biological phenomenon. Deviations from this occur rarely (8%) and do not conform to the norm. The pH value stabilization in connection with this crucial early postnatal phase occurs to such a high degree that, without stagnation, on average all experimentees show pH values between 7,270 and 7,300 after 180 minutes of life-regardless of which vitality group they belong to. After reaching this common value at the end of the third hour of life, the further development of the ph values and the consequential resulting parameters in all three vitality groups are similar. A stagnation of the rising pH value between the 4th and 12th hour of life was established during the examination. Moderate stabilization then set in after this phase. Between the 24th and 36th hour of life all experimentees reached an average highest pH value of 7,400. Until the end of the examination period, however, this then dropped slightly to values between 7,380 and 7,395.

摘要

本研究的目的是描述新生牛犊出生后96小时内酸碱状态的变化。由于采血间隔时间短,记录了新生牛犊出生后最初几分钟和几小时内酸碱状态的明显波动。本研究共使用了临床提供的25头DSB、DRB和DFV品种的成熟且营养良好的犊牛。除了使用阿氏评分对新生儿的生命体征进行出生后即时临床评估外,还同时测定了pH值、当前碱剩余和二氧化碳分压。随后在适应的第一阶段对酸碱状态进行进一步的连续评估。仅为此,在分娩后的前60分钟内从颈静脉采集了12份血样。直到出生后第四天检查期结束,每个实验对象总共进行了26次测量。根据最初临床和实验室观察得出的具体结果,实验对象可分为不同的活力类别。所有犊牛的酸碱状态在出生后的最初几分钟内都会恶化,这表明在出生后所有活力方面的pH值和碱剩余均明显低于初始水平。平均而言,最低pH值在出生后第3至15分钟之间达到,并在此期间保持比初始值低0.019至0.096。随后pH值会有不同程度的快速上升,同时碱差值也会趋于平衡。尽管随着酸碱状态的发展存在个别差异,但出生后最初几分钟内pH值的降低被认为是一种正常的生物学现象。很少出现与此不同的情况(8%),且不符合正常标准。与这个关键的出生后早期阶段相关的pH值稳定程度很高,以至于在没有停滞的情况下,平均而言,所有实验对象在出生后180分钟时的pH值都在7.270至7.300之间,无论它们属于哪个活力组。在出生后第三小时末达到这个共同值后,所有三个活力组的pH值及其相应参数的进一步发展情况相似。在检查过程中发现,出生后第4至12小时之间pH值上升出现停滞。在此阶段之后,适度稳定状态开始出现。在出生后第24至36小时之间,所有实验对象的平均最高pH值达到7.400。然而,直到检查期结束,pH值随后会略有下降,降至7.380至7.395之间。

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