Hoshino Y, Yoshikawa K, Inoue Y, Asai S, Nakamura T, Ogino T, Umeda M, Iwamoto A
Department of Infectious Diseases, University of Tokyo, Japan.
Radiat Med. 1999 Mar-Apr;17(2):115-20.
The reproducibility of short echo time proton MR spectroscopy (1H-MRS) in normal human brains was examined. Thirteen healthy volunteers were studied, and each underwent three MRS examinations. Second and third measurements were done on the same day, about two months after the first measurement, and interday and intraday reproducibility were evaluated. MRS was performed with proton brain examination/single voxel (PROBE/SV) and point-resolved spatially localized spectroscopy (PRESS) (repetition time = 2000 ms, echo time = 30 ms). Five metabolite ratios were computed; N-acetyl-aspartate (NAA)/creatine (Cr), choline (Cho)/Cr, myo-inositol (mI)/Cr, NAA/(NAA + Cr + Cho), and NAA/Cho. Their normal range and reproducibility were measured. For each metabolite ratio, there was no significant difference between interday difference and intraday difference, suggesting that the interval of two months has minimal effect on MRS measurements. MRS may be utilized for the observation of central nervous system diseases.
对正常人类大脑中短回波时间质子磁共振波谱（1H-MRS）的可重复性进行了研究。对13名健康志愿者进行了研究，每人接受了三次MRS检查。第二次和第三次测量在同一天进行，大约在第一次测量后两个月，评估了日间和日内的可重复性。使用质子脑检查/单体素（PROBE/SV）和点分辨空间定位波谱（PRESS）（重复时间 = 2000 ms，回波时间 = 30 ms）进行MRS检查。计算了五个代谢物比率；N-乙酰天门冬氨酸（NAA）/肌酸（Cr）、胆碱（Cho）/Cr、肌醇（mI）/Cr、NAA/（NAA + Cr + Cho）和NAA/Cho。测量了它们的正常范围和可重复性。对于每个代谢物比率，日间差异和日内差异之间没有显著差异，这表明两个月的间隔对MRS测量的影响最小。MRS可用于观察中枢神经系统疾病。
