D-glucosamine propanedithioacetal, an efficient chiral auxiliary in beta-lactam chemistry.
作者信息
Anaya J, Gero S D, Grande M, Hernando J I, Laso N M
机构信息
Departamento de Química Orgánica, Universidad de Salamanca, Spain.
出版信息
Bioorg Med Chem. 1999 May;7(5):837-50. doi: 10.1016/s0968-0896(98)00264-8.
Abstract
The synthesis of some monocyclic beta-lactams (monobactams) by the Staudinger reaction using D-glucosamine propanedithioacetal as chiral auxiliary is reported. The influence of several radicals at C3, C4, and C1' (sugar moiety) as well as other structural aspects are considered in relation to the antielastase activity.
摘要
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