核糖体蛋白mRNA翻译对脊髓灰质炎病毒诱导的蛋白质合成阻断的抗性。
Resistance of ribosomal protein mRNA translation to protein synthesis shutoff induced by poliovirus.
作者信息
Cardinali B, Fiore L, Campioni N, De Dominicis A, Pierandrei-Amaldi P
机构信息
Istituto di Biologia Cellulare CNR, Istituto Superiore di Sanita', Rome, Italy.
出版信息
J Virol. 1999 Aug;73(8):7070-6. doi: 10.1128/JVI.73.8.7070-7076.1999.
Abstract
Poliovirus infection induces an overall inhibition of host protein synthesis, although some mRNAs continue to be translated, suggesting different translation requirements for cellular mRNAs. It is known that ribosomal protein mRNAs are translationally regulated and that the phosphorylation of ribosomal protein S6 is involved in the regulation. Here, we report that the translation of ribosomal protein mRNAs resists poliovirus infection and correlates with an increase in p70(s6k) activity and phosphorylation of ribosomal protein S6.
摘要
脊髓灰质炎病毒感染会导致宿主蛋白质合成全面受到抑制，尽管一些信使核糖核酸（mRNA）仍在继续翻译，这表明细胞内mRNA的翻译需求有所不同。已知核糖体蛋白mRNA的翻译受到调控，并且核糖体蛋白S6的磷酸化参与了这一调控过程。在此，我们报告核糖体蛋白mRNA的翻译能够抵抗脊髓灰质炎病毒感染，并且与p70（s6k）活性的增加以及核糖体蛋白S6的磷酸化相关。
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