Weeks R A, Gerloff C, Honda M, Dalakas M C, Hallett M
Human Motor Control Section, Medical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892-1428, USA.
J Neurophysiol. 1999 Jul;82(1):484-8. doi: 10.1152/jn.1999.82.1.484.
Movement-related cerebellar activation may be due to sensory or motor processing. Ordinarily, sensory and motor processing are obligatorily linked, but in patients who have severe pansensory neuropathies with normal muscle strength, motor activity occurs in isolation. In the present study, positron emission tomography and functional magnetic resonance imaging in such patients showed no cerebellar activation with passive movement, whereas there was prominent movement-related cerebellar activation despite absence of proprioceptive or visual input. The results indicate that motor processing occurs within the cerebellum and do not support the recently advanced view that the cerebellum is primarily a sensory organ.
与运动相关的小脑激活可能源于感觉或运动处理。通常情况下，感觉和运动处理必然相互关联，但在肌肉力量正常却患有严重全感觉神经病变的患者中，运动活动是孤立发生的。在本研究中，对这类患者进行的正电子发射断层扫描和功能磁共振成像显示，被动运动时小脑无激活，而尽管缺乏本体感觉或视觉输入，仍存在显著的与运动相关的小脑激活。结果表明，运动处理在小脑内发生，并不支持最近提出的小脑主要是一个感觉器官的观点。
