Vardinon N, Yust I, Katz O, Iaina A, Katzir Z, Modai D, Burke M
Department of Medicine A, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.
Am J Kidney Dis. 1999 Jul;34(1):146-9. doi: 10.1016/s0272-6386(99)70121-6.
In a group of 520 patients undergoing chronic hemodialysis, 23 (4. 4%) were enzyme immunoassay (EIA) positive for human immunodeficiency virus (HIV) and indeterminate by Western blot (IWB) analysis. The antibodies were mostly directed against p24 and p55 antigens. A comparison between hemodialysis patients with and without IWB showed significant differences between the two groups with respect to number of units of blood transfused, history of renal transplant rejection, and Rh status. No significant differences were observed with respect to ethnic group, nature of renal disease, duration of hemodialysis, associated diseases, and ABO blood group. The HIV IWB phenomenon may represent abnormal immune reactivity as a result of transplantation antigens and/or autoantibody formation. Five-year follow-up of the HIV EIA-positive IWB patients showed that none had seroconverted to HIV-positive status.
在一组520例接受慢性血液透析的患者中，23例（4.4%）通过酶免疫测定（EIA）检测人类免疫缺陷病毒（HIV）呈阳性，但经蛋白质印迹法（IWB）分析结果不确定。这些抗体大多针对p24和p55抗原。对IWB阳性和阴性的血液透析患者进行比较后发现，两组在输血单位数量、肾移植排斥史和Rh血型方面存在显著差异。在种族、肾病性质、血液透析持续时间、相关疾病和ABO血型方面未观察到显著差异。HIV-IWB现象可能代表由于移植抗原和/或自身抗体形成导致的异常免疫反应。对HIV-EIA阳性IWB患者进行的五年随访显示，没有人血清转化为HIV阳性状态。
