Hirayasu Y, Shenton M E, Salisbury D F, Kwon J S, Wible C G, Fischer I A, Yurgelun-Todd D, Zarate C, Kikinis R, Jolesz F A, McCarley R W
Department of Psychiatry, Harvard Medical School, Boston, MA, USA.
Am J Psychiatry. 1999 Jul;156(7):1091-3. doi: 10.1176/ajp.156.7.1091.
Gray matter volume and glucose utilization have been reported to be reduced in the left subgenual cingulate of subjects with familial bipolar or unipolar depression. It is unclear whether these findings are secondary to recurrent illness or are part of a familial/genetic syndrome. The authors' goal was to clarify these findings.
Volumetric analyses were performed by using magnetic resonance imaging in 41 patients experiencing their first episode of affective disorder or schizophrenia and in 20 normal comparison subjects.
The left subgenual cingulate volume of the patients with affective disorder who had a family history of affective disorder was smaller than that of patients with affective disorder with no family history of the illness and the normal comparison subjects. Patients with schizophrenia did not differ from comparison subjects in left subgenual cingulate volume.
Left subgenual cingulate abnormalities are present at first hospitalization for psychotic affective disorder in patients who have a family history of affective disorder.
据报道，患有家族性双相或单相抑郁症的受试者左膝下扣带回的灰质体积和葡萄糖利用率降低。尚不清楚这些发现是复发性疾病的继发结果还是家族性/遗传综合征的一部分。作者的目标是阐明这些发现。
对41例首次发作情感障碍或精神分裂症的患者以及20名正常对照受试者进行磁共振成像体积分析。
有情感障碍家族史的情感障碍患者的左膝下扣带回体积小于无情感障碍家族史的情感障碍患者和正常对照受试者。精神分裂症患者的左膝下扣带回体积与对照受试者无差异。
有情感障碍家族史的患者在首次因精神病性情感障碍住院时就存在左膝下扣带回异常。
