O'Gara B A, Illuzzi F A, Chung M, Portnoy A D, Fraga K, Frieman V B
Department of Biological Sciences, Barnard College of Columbia University, New York, NY 10027-6598, USA.
Gen Pharmacol. 1999 Jun;32(6):669-81. doi: 10.1016/s0306-3623(98)00235-3.
Stimulation of the serotoninergic innervation of the leech pharynx or application of serotonin to the isolated pharynx induced four distinct types of contractile activity: an increase in basal tonus, large phasic contractions of 10-15 s in duration, smaller phasic contractions occurring at approximately 1 Hz, and a relaxation after washout of serotonin. Application to the isolated pharynx of the selective serotonin agonists (+/-)-8-hydroxy-2-(di-n-propylamino)tetralin, N-(3-trifluoromethylphenyl)piperazine, 1-(m-chlorophenyl)-piperazine, (+/-)-2,5-dimethoxy-4-iodoamphetamine, 2-methyl-5-hydroxytrypamine, alpha-methyl-5-hydroxytryptamine, and 5-methoxytryptamine induced distinct types of pharyngeal contractile activity. The results of this study suggest that the leech pharynx possesses more than one type of serotonin receptor.
刺激水蛭咽部的5-羟色胺能神经支配或向离体咽部施用5-羟色胺可诱导出四种不同类型的收缩活动：基础张力增加、持续10 - 15秒的大幅度相性收缩、以约1赫兹频率发生的较小幅度相性收缩以及在洗去5-羟色胺后的松弛。向离体咽部施用选择性5-羟色胺激动剂（±）-8-羟基-2-（二正丙基氨基）四氢萘、N-（3-三氟甲基苯基）哌嗪、1-（间氯苯基）哌嗪、（±）-2,5-二甲氧基-4-碘苯丙胺、2-甲基-5-羟基色胺、α-甲基-5-羟色胺和5-甲氧基色胺可诱导出不同类型的咽部收缩活动。本研究结果表明，水蛭咽部拥有不止一种类型的5-羟色胺受体。
