Tamaki S, Iwai N, Tsujita Y, Nakamura Y, Ohmichi N, Kinoshita M
Int J Cardiol. 1999 Jun 1;69(3):309-11. doi: 10.1016/s0167-5273(99)00019-4.
In the present study, we assessed the significance of the Trp64Arg mutation in the beta3-adrenergic receptor gene in 428 Japanese subjects, including 198 subjects who underwent coronary angiography for possible ischemic heart diseases (IHD group) and 230 non-IHD subjects (control group). We conclude that the Trp64Arg polymorphism of the beta3-adrenergic receptor gene did not appear to have any pathophysiological significance in Japanese subjects.
在本研究中，我们评估了428名日本受试者β3 - 肾上腺素能受体基因中色氨酸64位精氨酸（Trp64Arg）突变的意义，其中包括198名因可能患有缺血性心脏病而接受冠状动脉造影的受试者（缺血性心脏病组）和230名非缺血性心脏病受试者（对照组）。我们得出结论，在日本受试者中，β3 - 肾上腺素能受体基因的Trp64Arg多态性似乎没有任何病理生理学意义。
