Stähr P, Rupprecht H J, Voigtländer T, Post F, Otto M, Erbel R, Meyer J
Second Medical Clinic, Johannes-Gutenberg-University, Mainz, Germany.
Catheter Cardiovasc Interv. 1999 Jul;47(3):381-9. doi: 10.1002/(sici)1522-726x(199907)47:3<381::aid-ccd29>3.0.co;2-#.
In this study we examined a new thrombectomy catheter device. Different kinds of in vitro generated thrombi and cadaver thrombi were disrupted in test tubes. The mean disruption rate (and disruption time for 1 g of thrombus) was 225 +/- 65 mg/sec (5 +/- 2 sec) for whole-blood, 117 +/- 60 mg/sec (12 +/- 9 sec) for fibrin, 41 +/- 18 mg/sec (30 +/- 18 sec) for mixed, 70 +/- 42 mg/sec (17 +/- 5 sec) for unorganized, 45 +/- 8 mg/sec (22 +/- 4 sec) for partly, and 5 +/- 1 mg/sec (216 +/- 29 sec) for completely organized cadaver thrombi (P < 0.05). More than 99% of fragmented particles of whole-blood thrombi were 0-12 microm in diameter. The particle size of fibrin, mixed, and cadaver thrombi was similar, with 25%-40% of particles between 0-12 microm, 55%-71% >12-24 microm, and 2%-7% >24 microm. The device may be effectively used in the therapy of massive pulmonary embolism or acute peripheral and coronary artery syndromes when medical thrombolysis is contraindicated and organization of thrombus is absent. Further studies need to be performed to investigate the potential effects of particle microembolization. Cathet. Cardiovasc. Intervent. 47:381-389, 1999.
在本研究中，我们检测了一种新型血栓切除术导管装置。不同种类的体外生成血栓和尸体血栓在试管中被破坏。全血血栓的平均破坏率（及每克血栓的破坏时间）为225±65毫克/秒（5±2秒），纤维蛋白血栓为117±60毫克/秒（12±9秒），混合血栓为41±18毫克/秒（30±18秒），无结构血栓为70±42毫克/秒（17±5秒），部分机化血栓为45±8毫克/秒（22±4秒），完全机化尸体血栓为5±1毫克/秒（216±29秒）（P<0.05）。全血血栓破碎颗粒直径超过99%在0至12微米之间。纤维蛋白血栓、混合血栓和尸体血栓的颗粒大小相似，0至12微米之间的颗粒占25%至40%，12至24微米之间的占55%至71%，大于24微米的占2%至7%。当药物溶栓禁忌且血栓未机化时，该装置可有效用于治疗大面积肺栓塞或急性外周及冠状动脉综合征。需要进一步研究以调查颗粒微栓塞的潜在影响。《心血管介入导管术》47:381 - 389，1999年。
