Peñarrubia J, Balasch J, Fábregues F, Creus M, Cívico S, Vanrell J A
Institut Clínic of Gynecology, Obstetrics and Neonatology, Faculty of Medicine, Barcelona, Spain.
Hum Reprod. 1999 Jul;14(7):1703-6. doi: 10.1093/humrep/14.7.1703.
We report a case of a patient with polycystic ovary syndrome and primary infertility who was admitted to our in-vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) programme because of her partner's severe oligozoospermia and asthenozoospermia. Ovarian stimulation was accomplished in the three treatment cycles using gonadotrophin therapy after a dual approach with ovarian suppression using oral contraceptive pills followed by gonadotrophin-releasing hormone agonist therapy. Oocyte retrieval was unsuccessful in the first two treated cycles despite the fact that human chorionic gonadotrophin (HCG) from three different batches was used. In the third treatment cycle, recombinant HCG was used and five oocytes were retrieved. This is the first report of recurrent empty follicle syndrome despite the use of different batches of commercially available urinary HCG, and of its successful treatment using recombinant HCG.
我们报告了一例多囊卵巢综合征并原发性不孕的患者，因其伴侣严重少弱精子症而进入我们的体外受精（IVF）/卵胞浆内单精子注射（ICSI）项目。在采用口服避孕药进行卵巢抑制然后进行促性腺激素释放激素激动剂治疗的双重方法后，使用促性腺激素疗法在三个治疗周期中完成了卵巢刺激。尽管使用了来自三个不同批次的人绒毛膜促性腺激素（HCG），但在前两个治疗周期中取卵均未成功。在第三个治疗周期中，使用了重组HCG并获取了5个卵母细胞。这是首例关于尽管使用了不同批次的市售尿源性HCG仍反复出现空卵泡综合征，以及使用重组HCG成功治疗该综合征的报告。
