Heeke D S, White M P, Mele G D, Hanifin J P, Brainard G C, Rollag M D, Winget C M, Holley D C
Department of Biological Sciences, San Jose State University, California, USA.
Lab Anim Sci. 1999 Jun;49(3):297-304.
A novel light-emitting diode (LED) light source for use in animal-habitat lighting was evaluated.
The LED was evaluated by comparing its effectiveness with that of cool white fluorescent light (CWF) in suppressing pineal gland melatonin content and maintaining normal retinal physiology, as evaluated by use of electroretinography (ERG), and morphology.
Pineal melatonin concentration was equally suppressed by LED and CWF light at five light illuminances (100, 40, 10, 1, and 0.1 lux). There were no significant differences in melatonin suppression between LED and CWF light, compared with values for unexposed controls. There were no differences in ERG a-wave implicit times and amplitudes or b-wave implicit times and amplitudes between 100-lux LED-exposed rats and 100-lux CWF-exposed rats. Results of retinal histologic examination indicated no differences in retinal thickness, rod outer segment length, and number of rod nuclei between rats exposed to 100-lux LED and 100-lux CWF for 14 days. Furthermore, in all eyes, the retinal pigmented epithelium was intact and not vacuolated, whereas rod outer segments were of normal thickness.
LED light does not cause retinal damage and can suppress pineal melatonin content at intensities similar to CWF light intensities.
对一种用于动物栖息地照明的新型发光二极管（LED）光源进行评估。
通过比较LED与冷白色荧光灯（CWF）在抑制松果体褪黑素含量以及维持正常视网膜生理功能（通过视网膜电图（ERG）评估）和形态方面的有效性来评估LED。
在五种光照强度（100、40、10、1和0.1勒克斯）下，LED和CWF光对松果体褪黑素浓度的抑制作用相同。与未暴露对照组的值相比，LED和CWF光在褪黑素抑制方面无显著差异。在暴露于100勒克斯LED的大鼠和暴露于100勒克斯CWF的大鼠之间，ERG a波潜伏期和振幅或b波潜伏期和振幅没有差异。视网膜组织学检查结果表明，暴露于100勒克斯LED和100勒克斯CWF 14天的大鼠在视网膜厚度、视杆外段长度和视杆细胞核数量方面没有差异。此外，在所有眼睛中，视网膜色素上皮完整且无空泡形成，而视杆外段厚度正常。
LED光在与CWF光强度相似的强度下不会导致视网膜损伤，并且可以抑制松果体褪黑素含量。
