三萜皂苷的抗病毒活性机制。

Mechanism of antiviral activity of triterpenoid saponins.

作者信息

Simões C M, Amoros M, Girre L

机构信息

Department of Pharmaceutical Sciences, Universidade Federal de Santa Catarina, Florianópolis, Brazil.

出版信息

Phytother Res. 1999 Jun;13(4):323-8. doi: 10.1002/(SICI)1099-1573(199906)13:4<323::AID-PTR448>3.0.CO;2-C.

DOI:10.1002/(SICI)1099-1573(199906)13:4<323::AID-PTR448>3.0.CO;2-C

PMID:10404540

Abstract

Triterpenoid saponins are naturally occurring sugar conjugates of triterpenes possessing various biological activities, including antiviral action. Two substances isolated from natural sources were tested against herpes simplex virus type 1 replication. They did not show evidence of cytotoxicity under antiviral test conditions. The triterpenoid saponin, isolated from a Brazilian plant (s21), represents the oleanane group and inhibited herpes simplex virus type 1 DNA synthesis. The triterpenoid saponin, isolated from a Chinese plant (s17), represents the ursane group and seemed to inhibit viral capsid protein synthesis of herpes simplex virus type 1.

摘要

三萜皂苷是天然存在的三萜糖缀合物，具有多种生物活性，包括抗病毒作用。对从天然来源分离出的两种物质进行了抗1型单纯疱疹病毒复制的测试。在抗病毒测试条件下，它们未显示出细胞毒性迹象。从一种巴西植物中分离出的三萜皂苷（s21）属于齐墩果烷型，可抑制1型单纯疱疹病毒的DNA合成。从一种中国植物中分离出的三萜皂苷（s17）属于乌苏烷型，似乎可抑制1型单纯疱疹病毒的病毒衣壳蛋白合成。