Simões C M, Amoros M, Girre L
Department of Pharmaceutical Sciences, Universidade Federal de Santa Catarina, Florianópolis, Brazil.
Phytother Res. 1999 Jun;13(4):323-8. doi: 10.1002/(SICI)1099-1573(199906)13:4<323::AID-PTR448>3.0.CO;2-C.
Triterpenoid saponins are naturally occurring sugar conjugates of triterpenes possessing various biological activities, including antiviral action. Two substances isolated from natural sources were tested against herpes simplex virus type 1 replication. They did not show evidence of cytotoxicity under antiviral test conditions. The triterpenoid saponin, isolated from a Brazilian plant (s21), represents the oleanane group and inhibited herpes simplex virus type 1 DNA synthesis. The triterpenoid saponin, isolated from a Chinese plant (s17), represents the ursane group and seemed to inhibit viral capsid protein synthesis of herpes simplex virus type 1.
三萜皂苷是天然存在的三萜糖缀合物，具有多种生物活性，包括抗病毒作用。对从天然来源分离出的两种物质进行了抗1型单纯疱疹病毒复制的测试。在抗病毒测试条件下，它们未显示出细胞毒性迹象。从一种巴西植物中分离出的三萜皂苷（s21）属于齐墩果烷型，可抑制1型单纯疱疹病毒的DNA合成。从一种中国植物中分离出的三萜皂苷（s17）属于乌苏烷型，似乎可抑制1型单纯疱疹病毒的病毒衣壳蛋白合成。
