Ura H, Yamada N, Torii H, Imakado S, Iozumi K, Shimada S
Department of Dermatology, Tokyo University Branch Hospital, Japan.
J Dermatol. 1999 Jun;26(6):385-9. doi: 10.1111/j.1346-8138.1999.tb03494.x.
We report a case of histiocytic necrotizing lymphadenitis in a 28-year-old woman. The biopsy specimen of the enlarged lymph node showed lymphocytes, histiocytes, and a large amount of nuclear debris as well as marked eosinophilic deposits. We found DNA fragments by means of the modified TUNEL method, especially in the transitional area between intact cells and the foci of eosinophilic deposits and the cells positive for anti-Fas antibody in the biopsied lymph node. Therefore, the necrotic appearance of the lymph node was thought to be caused by apoptosis induced by the Fas-Fas ligand system. We hypothesize that the apoptosis was strongly related to the pathogenesis of this disease.
我们报告一例28岁女性组织细胞性坏死性淋巴结炎。肿大淋巴结的活检标本显示有淋巴细胞、组织细胞、大量核碎片以及明显的嗜酸性沉积物。我们通过改良的TUNEL法发现了DNA片段，尤其在活检淋巴结中完整细胞与嗜酸性沉积物灶之间的过渡区域以及抗Fas抗体阳性的细胞中。因此，淋巴结的坏死表现被认为是由Fas-Fas配体系统诱导的细胞凋亡所致。我们推测这种细胞凋亡与该疾病的发病机制密切相关。
