Mouriaux F, Martinot V, Pellerin P, Patenotre P, Rouland J F, Constantinides G
Division of Ophthalmology, Claude Huriez Hospital, Lille, France.
Acta Ophthalmol Scand. 1999 Jun;77(3):326-30. doi: 10.1034/j.1600-0420.1999.770316.x.
In order to further assess the survival value of orbital exenteration in malignant orbital and periorbital tumors.
The charts of 44 patients exenterated for a neoplasm of the orbit or periorbit were reviewed in a retrospective study.
The overall 4-year survival was 45%. 26 patients had free margins on histological examination and 24 patients had developed local recurrence or metastasis. Local recurrence or metastasis were significantly more common in the group with transected margins than in the group with free-margins (p= 0.01). Survival between the group of patients with local recurrence or metastasis and the group without local recurrence or metastasis showed statistically significant difference (p=0.0025). In contrast, survival between the group of patients with free margins and the group with transected margins did not show statistically significant difference (p=0.13).
Surgical free margins section is a key element in successful cancer surgery but seems not the only prognosis variable.
为了进一步评估眼眶内容剜除术在恶性眼眶及眶周肿瘤中的生存价值。
对44例行眼眶或眶周肿瘤剜除术患者的病历进行回顾性研究。
4年总生存率为45%。26例患者组织学检查切缘阴性，24例出现局部复发或转移。切缘阳性组局部复发或转移明显比切缘阴性组更常见（p = 0.01）。局部复发或转移患者组与无局部复发或转移患者组之间的生存率有统计学显著差异（p = 0.0025）。相比之下，切缘阴性患者组与切缘阳性患者组之间的生存率无统计学显著差异（p = 0.13）。
手术切缘阴性是癌症手术成功的关键因素，但似乎不是唯一的预后变量。
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