Prichard S
Department of Medicine, McGill University Health Centre, Royal Victoria Hospital, Montreal, Québec, Canada.
Perit Dial Int. 1999;19 Suppl 2:S133-7.
Uremia in general and peritoneal dialysis in particular bring with them risk factors for the development of cardiovascular disease. These factors include multiple lipid abnormalities, hyperhomocysteinemia, abdominal obesity, chronic inflammation, hypoalbuminemia, oxidative stress, and AGE formation. When these are combined with conventional risk factors, one can appreciate why the incidence of cardiovascular disease is so high in peritoneal dialysis patients. Treatment strategies should address each of these risks appropriately.
一般而言，尿毒症尤其是腹膜透析会带来心血管疾病发生的危险因素。这些因素包括多种脂质异常、高同型半胱氨酸血症、腹部肥胖、慢性炎症、低白蛋白血症、氧化应激和晚期糖基化终末产物的形成。当这些因素与传统危险因素相结合时，就可以理解为什么腹膜透析患者的心血管疾病发病率如此之高。治疗策略应适当针对每一项此类风险。
