Fang X, Ledingham KW, Graham P, Smith DJ, McCanny T, Singhal RP, Langley AJ, Taday PF
Department of Physics and Astronomy, University of Glasgow, Glasgow G12 8QQ, Scotland, UK.
Rapid Commun Mass Spectrom. 1999;13(14):1390-7. doi: 10.1002/(SICI)1097-0231(19990730)13:14<1390::AID-RCM650>3.0.CO;2-T.
The potential of femtosecond laser time-of-flight mass spectrometry (FLMS) for uniform quantitative analysis of molecules has been investigated. Various samples of molecular gases and vapours have been studied, using ultra-fast ( approximately 50 fs) laser pulses with very high intensity (up to 1.6 x 10(16) Wcm(-2)) for non-resonant multiphoton ionisation/tunnel ionisation. Some of these molecules have high ionisation potentials, requiring up to ten photons for non-resonant ionisation. The relative sensitivity factors (RSF) have been determined as a function of the laser intensity and it has been demonstrated that for molecules with very different masses and ionisation potentials, uniform ionisation has been achieved at the highest laser intensities. Quantitative laser mass spectrometry of molecules is therefore a distinct possibility. Copyright 1999 John Wiley & Sons, Ltd.
研究了飞秒激光飞行时间质谱法（FLMS）对分子进行均匀定量分析的潜力。使用超快（约50飞秒）且强度极高（高达1.6×10¹⁶Wcm⁻²）的激光脉冲对分子气体和蒸汽的各种样品进行非共振多光子电离/隧道电离研究。其中一些分子具有高电离势，非共振电离需要多达十个光子。已确定相对灵敏度因子（RSF）作为激光强度的函数，并且已经证明，对于质量和电离势差异很大的分子，在最高激光强度下实现了均匀电离。因此，分子的定量激光质谱分析具有明显的可能性。版权所有1999 John Wiley & Sons, Ltd.
