van Noorden G K
Klin Monbl Augenheilkd. 1978 Oct;173(4):464-9.
Experiments in animal models revealed that unilateral lidclosure, artificial esotropia or anisometropia cause amblyopia comparable to that occuring in humans and produces morphological and functional anomalies in the visual centers. Form vision deprivation and abnormal binocular interaction have been identified as amblyopiogenic factors. The age of susceptibility for amblyopia in humams needs better definition. Uncontrolled occlusion in infants must be avoided and congenital or traumatic cataracts occuring in infancy should be operated upon as early as possible and the aphakic eye(s) optically corrected without delay to prevent deprivation amblyopia.
动物模型实验表明,单侧眼睑闭合、人为性内斜视或屈光参差会导致与人类相似的弱视,并在视觉中枢产生形态和功能异常。形觉剥夺和异常双眼相互作用已被确认为致弱视因素。人类弱视的易感性年龄需要更明确的界定。必须避免婴儿期无控制的遮盖,婴儿期发生的先天性或外伤性白内障应尽早手术,无晶状体眼应立即进行光学矫正,以预防剥夺性弱视。