Sundmacher R
Klin Monbl Augenheilkd. 1978 Oct;173(4):516-9.
In a randomized double-blind study trifluorothymidine was tested for its ability to prevent dendritic keratitis at a dose of 5 drops daily in patients with steroid-treated herpetic keratouveitis. The corneal epithelium of all 56 patients in the study was free of viral foci prior to initiation of therapy. In the placebo- "protected" group, 6 of 28 patients developed virologically confirmed dendritic keratitis while they were under steroids, whereas all 28 trifluorothymidine-protected patients showed uneventful courses of their steroid regimes. No clinically relevant side-effects of trifluorothymidine prophylaxis were observed in this study.
在一项随机双盲研究中，对三氟胸苷进行了测试，以评估其在接受类固醇治疗的疱疹性角膜葡萄膜炎患者中，每日5滴剂量预防树枝状角膜炎的能力。研究中所有56例患者在治疗开始前角膜上皮均无病毒病灶。在安慰剂“保护”组中，28例患者中有6例在使用类固醇期间发生了病毒学确诊的树枝状角膜炎，而所有28例接受三氟胸苷保护的患者在使用类固醇期间病情均平稳。本研究未观察到三氟胸苷预防治疗的临床相关副作用。
