Chatterjee A, Deb S
Department of Zoology, North-Eastern Hill University, Shillong, India.
Cancer Lett. 1999 May 3;139(1):23-31. doi: 10.1016/s0304-3835(98)00364-4.
The carcinogenic potentiality of the major alkaloid of betel nut, arecoline (ARC), is well established. This study was undertaken to determine the differences in genotoxic effects of ARC when given by two different routes (oral administration (OA) and intraperitoneal injection (IP)) in mouse bone marrow cells (BMC) since ARC carcinogenicity was observed only when ARC was given orally. The data indicate that ARC-OA induced a higher frequency of cancers, a greater delay in the cell cycle and greater sister chromatid exchanges than ARC-IP. The presence of N-acetyl cysteine along with ARC-OA significantly reduced the effect of ARC.
槟榔主要生物碱槟榔碱（ARC）的致癌潜力已得到充分证实。本研究旨在确定ARC通过两种不同途径（口服给药（OA）和腹腔注射（IP））给予小鼠骨髓细胞（BMC）时的遗传毒性效应差异，因为仅在口服ARC时观察到ARC致癌性。数据表明，与ARC-IP相比，ARC-OA诱导的癌症频率更高，细胞周期延迟更大，姐妹染色单体交换更多。N-乙酰半胱氨酸与ARC-OA同时存在可显著降低ARC的作用。
