Siddique Yasir Hasan, Ara Gulshan, Beg Tanveer, Afzal Mohammad
Section of Genetics, Department of Zoology, Faculty of Life Sciences, Aligarh Muslim University, Aligarh, UP, 202 002, India.
J Nat Med. 2008 Jan;62(1):52-6. doi: 10.1007/s11418-006-0108-5. Epub 2007 Sep 28.
Nordihydroguaiaretic acid (NDGA), a phenolic lignan, was tested for its antigenotoxic potential against chlormadinone acetate (CMA)-induced genotoxic damage in mice bone-marrow cells. Doses of about 22.50 mg/kg body weight of CMA were given along with 1, 5 and 10 mg/kg body weight of NDGA intraperitoneally. The treatment resulted in the reduction of sister chromatid exchanges and chromosomal aberrations induced by CMA, suggesting an antigenotoxic potential of NDGA. Earlier studies show that CMA generates reactive oxygen species, responsible for genotoxic damage. The free radical-scavenging property of NDGA is responsible for the reduction of genotoxic damage induced by CMA in mice bone-marrow cells.
去甲二氢愈创木酸（NDGA），一种酚性木脂素，针对醋酸氯地孕酮（CMA）诱导的小鼠骨髓细胞遗传毒性损伤，对其抗遗传毒性潜力进行了测试。腹腔注射约22.50mg/kg体重的CMA，同时分别注射1、5和10mg/kg体重的NDGA。该处理导致CMA诱导的姐妹染色单体交换和染色体畸变减少，表明NDGA具有抗遗传毒性潜力。早期研究表明，CMA会产生活性氧，这是造成遗传毒性损伤的原因。NDGA的自由基清除特性可减少CMA在小鼠骨髓细胞中诱导的遗传毒性损伤。
