Wang T C, Dockray G J
Gastrointestinal Unit and Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.
Am J Physiol. 1999 Jul;277(1):G6-11. doi: 10.1152/ajpgi.1999.277.1.G6.
The role of gastrin in the regulation of gastrointestinal growth and acid secretion has been addressed through recent studies involving transgenic and knockout mice. The role of gastrin as a key modulator of parietal cell function and gastric acid secretion has been confirmed through studies in mice deficient in either gastrin or the gastrin/CCK-B receptor. However, although gastrin-deficient mice show no changes in gastric proliferation, they do show reduced colonic proliferation, and rates of colonic proliferation are increased in transgenic mice overexpressing glycine-extended gastrin or progastrin. This themes article highlights recent progress in our understanding of the biology of gastrin through studies in genetically modified mice.
通过近期涉及转基因和基因敲除小鼠的研究，胃泌素在调节胃肠道生长和胃酸分泌中的作用已得到探讨。通过对缺乏胃泌素或胃泌素/CCK - B受体的小鼠进行研究，胃泌素作为壁细胞功能和胃酸分泌关键调节因子的作用已得到证实。然而，尽管缺乏胃泌素的小鼠胃增殖无变化，但结肠增殖确实减少，而在过表达甘氨酸延伸型胃泌素或前胃泌素的转基因小鼠中，结肠增殖速率增加。这篇主题文章强调了通过对基因改造小鼠的研究，我们在胃泌素生物学理解方面的最新进展。
