Namba Y, Kyakuno M, Nakamura T, Yamashiro H, Okada M, Toki K, Ichimaru N, Kokado Y, Takahara S, Okuyama A, Oka K, Imai E, Kyo M
Department of Urology, Osaka Seamen's Insurance Hospital.
Hinyokika Kiyo. 1999 May;45(5):349-53.
We report a case of subclinical immunoglobulin A (IgA) nephropathy and cyclosporin associated arteriolopathy following renal transplantation. A 39-year-old male with chronic glomerulonephritis received kidney transplantation from a two- human leukocyte antigen (HLA) mismatched cadaveric donor. The initial immunosuppressive therapy was triple-drug therapy with cyclosporin, prednisolone and mizoribine. Four months after transplantation, he had an acute rejection episode, and the renal function was recovered by steroid pulse and 15-deoxyspergualin therapy. Eight years after transplantation, we conducted a non-episode biopsy of the renal allograft to examine subclinical lesions. The histopathological findings showed cyclosporin associate arteriolopathy (CAA) and IgA nephropathy. There was no sign of acute or chronic rejection. At the present time, the renal function of the allograft is good. In conclusion, the non-episode biopsy of renal allograft is useful for examination of subclinical lesions.
我们报告了1例肾移植术后亚临床免疫球蛋白A（IgA）肾病合并环孢素相关性小动脉病的病例。一名39岁的慢性肾小球肾炎男性接受了来自一名2个人类白细胞抗原（HLA）不匹配的尸体供者的肾移植。初始免疫抑制治疗采用环孢素、泼尼松龙和咪唑立宾三联药物治疗。移植后4个月，他发生了一次急性排斥反应，通过类固醇冲击和15-去氧精胍菌素治疗肾功能得以恢复。移植后8年，我们对移植肾进行了非发作期活检以检查亚临床病变。组织病理学结果显示环孢素相关性小动脉病（CAA）和IgA肾病。没有急性或慢性排斥的迹象。目前，移植肾的肾功能良好。总之，移植肾非发作期活检对于检查亚临床病变是有用的。
