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[一种用于检测粪便样本中幽门螺杆菌感染的新型免疫酶分析方法的评估]

[The evaluation of a new immunoenzyme analysis for the detection of Helicobacter pylori infection in stool samples].

作者信息

Calvet X, Feu F, Forné M, Montserrat A, Elizalde J I, Viver J M, Gali N, Domínguez J

机构信息

Servicio de Medicina Interna, Corporació Sanitària del Parc Taulí, Sabadell, Barcelona.

出版信息

Gastroenterol Hepatol. 1999 Jun-Jul;22(6):270-2.

PMID:10410445
Abstract

BACKGROUND

Detection of bacterial antigen in stool specimens (HpSAT) is a new promising tool for diagnosing Helicobacter pylori infection.

OBJECTIVE

To evaluate diagnostic accuracy of HpSAT in the diagnosis of Helicobacter pylori infection.

PATIENTS AND METHODS

We evaluate the presence of Helicobacter pylori infection by the rapid urease test and the 13C-urea breath test in endoscopic biopsies. Patients who were positive for both tests were considered to have Helicobacter pylori infection. Patients negative for both tests were considered free of infection. The presence of Helicobacter pylori infection was also determined in stool specimens by means of HpSAT.

RESULTS

The sensitivity of HpSAT was 92.8%, the specificity 92.3%, the positive predictive value 98.1% and the negative predictive value 75%.

CONCLUSIONS

HpSAT is a reliable tool for diagnosing Helicobacter pylori infection.

摘要

背景

粪便标本中细菌抗原检测(HpSAT)是诊断幽门螺杆菌感染的一种新的有前景的工具。

目的

评估HpSAT在诊断幽门螺杆菌感染中的诊断准确性。

患者与方法

我们通过快速尿素酶试验和内镜活检中的13C-尿素呼气试验评估幽门螺杆菌感染情况。两项试验均为阳性的患者被认为感染了幽门螺杆菌。两项试验均为阴性的患者被认为未感染。还通过HpSAT测定粪便标本中幽门螺杆菌感染情况。

结果

HpSAT的敏感性为92.8%,特异性为92.3%,阳性预测值为98.1%,阴性预测值为75%。

结论

HpSAT是诊断幽门螺杆菌感染的可靠工具。

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