Limpaphayom K, Panyakhamlerd K, Taechakraichana N, Kukulprasong A, Chotnopparatpattara P, Chaikittisilpa S
Department of Obstetrics and Gynecology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
J Med Assoc Thai. 1999 Apr;82(4):347-51.
Skin and bone share a similar organic constituent (type I collagen) which decreases with time after menopause due to hypoestrogenism. The interdependence of skin and bone atrophy has been reported. This study was conducted to assess the predictive value of an ultrasonographic measurement of skin thickness in the diagnosis of osteopenia (BMD below -1.5 SD.) in perimenopausal and early postmenopausal women. All patients had skin thickness measured by the same radiologist and had a dual-energy X-ray absorptiometry (DEXA) scan of the lumbar spine and the femoral neck. Of the 77 women studied, the mean age was 50.9 +/- 3.0 years. Thirty patients were in perimenopause and 47 in early postmenopause. Mean skin thickness was 2.1 +/- 0.4 mm. Women with a skin thickness of < or = 1.7 mm carried a higher risk for developing osteopenia at the lumbar spine (odds ratio 8.41, 95% confidence interval 2.19-32.35) and the femoral neck (odds ratio 3.88, 95% CI 1.14-13.17). Patients with a skin thickness of > or = 2.4 mm had a lower probability of osteopenia at the lumbar spines (odds ratio 0.17, 95% CI 0.035-0.845) and the femoral neck (odds ratio 0.22, 95% CI 0.055-0.899). In conclusion, a low skin thickness measurement by ultrasonography may be used as an indicator for osteopenia in perimenopausal and early postmenopausal women.
皮肤和骨骼具有相似的有机成分（I型胶原蛋白），绝经后由于雌激素缺乏，这种成分会随时间减少。皮肤和骨骼萎缩的相互依存关系已有报道。本研究旨在评估超声测量皮肤厚度对围绝经期和绝经后早期女性骨质疏松症（骨密度低于-1.5标准差）诊断的预测价值。所有患者均由同一位放射科医生测量皮肤厚度，并进行腰椎和股骨颈的双能X线吸收法（DEXA）扫描。在研究的77名女性中，平均年龄为50.9±3.0岁。30名患者处于围绝经期，47名处于绝经后早期。平均皮肤厚度为2.1±0.4毫米。皮肤厚度≤1.7毫米的女性腰椎发生骨质疏松症的风险更高（优势比8.41，95%置信区间2.19-32.35），股骨颈也是如此（优势比3.88，95%置信区间1.14-13.17）。皮肤厚度≥2.4毫米的患者腰椎发生骨质疏松症的概率较低（优势比0.17，95%置信区间0.035-0.845），股骨颈也是如此（优势比0.22，95%置信区间0.055-0.899）。总之，超声测量的低皮肤厚度可作为围绝经期和绝经后早期女性骨质疏松症的一个指标。
