[叶内型肺隔离症表现为血清癌胚抗原、糖类抗原19-9和糖类抗原125升高，并与无症状肺曲霉病相关]

[Intralobar pulmonary sequestration presenting increased serum CEA, CA 19-9, and CA 125, and associated with asymptomatic pulmonary aspergillosis].

作者信息

Sekiya M, Chiba A, Ienaga H, Ueki J, Hasunuma K, Takahashi H, Dambara T, Miyamoto H, Uekusa K, Fukuchi Y

机构信息

Department of Respiratory Medicine, Juntendo University School of Medicine, Tokyo, Japan.

出版信息

Nihon Kokyuki Gakkai Zasshi. 1999 May;37(5):433-7.

PMID:10410550

Abstract

A 44-year-old woman was admitted to our hospital for further evaluation of a consolidated shadow in the left lower lobe and the evaluation of serum tumor markers (CEA 46.3 ng/ml, CA 19-9 1911 U/ml, and CA 125 103 U/ml). Chest computed tomography revealed an irregular shaped, low density mass shadow in the left S10 region, suggesting the diagnosis of pulmonary sequestration or bronchial atresia. However digital subtraction angiography failed to demonstrate an anomalous feeding artery. We could not rule out the possibility that a malignant lesion was included in the consolidated shadow. A left thoracotomy revealed an intralobar pulmonary sequestration of the left lower lobe. Hyphae of aspergillus were found in the lumen of the cystic bronchus of the resected lung. Immunohistochemical studies showed strong expression of CEA, CA 19-9, and CA 125 by bronchial epithelia in the pulmonary sequenstration. The serum values of tumor markers returned to their normal ranges after surgery.

摘要

一名44岁女性因左肺下叶实变影及血清肿瘤标志物（癌胚抗原46.3 ng/ml、糖类抗原19-9 1911 U/ml和糖类抗原125 103 U/ml）评估而入住我院。胸部计算机断层扫描显示左S10区域有一不规则形低密度肿块影，提示肺隔离症或支气管闭锁的诊断。然而，数字减影血管造影未能显示异常供血动脉。我们不能排除实变影中包含恶性病变的可能性。左开胸手术显示左肺下叶叶内型肺隔离症。在切除肺的囊状支气管腔内发现曲霉菌菌丝。免疫组织化学研究显示，肺隔离症中支气管上皮细胞强烈表达癌胚抗原、糖类抗原19-9和糖类抗原125。术后肿瘤标志物血清值恢复到正常范围。