Kull I, Hallner E, Lilja G, Ohman-Johansson A C, Oman H, Wickman M
Department of Environmental Health, Stockholm County Council, Stockholm, Sweden.
Pediatr Allergy Immunol. 1999 Feb;10(1):21-6. doi: 10.1034/j.1398-9995.1999.101019.x.
The aim of this study was to establish whether there is a link between sensitisation to peanut and exposure to peanut oil in vitamin A and D preparations. Forty-one children with a positive in vivo or in vitro test towards peanut were included. Twenty-one children had consumed vitamins A and D in oil solution, 14 in water solution, and 6 both types. Refined and unrefined peanut oils were obtained and skin prick test extracts were prepared. None of the children exhibited a positive SPT in response to the refined peanut extract. In contrast, 15 children exhibited a positive SPT to the unrefined extract. There was no significant difference in the number of children reacting clinically to peanut exposure who had received vitamins A and D in oil-based or water-based formulations. However, children with clinical allergy to peanut and who had exclusively consumed vitamin A and D in peanut oil, exhibited a greater number of different allergic symptoms upon consumption of peanut compared with clinical allergic children who had consumed the vitamins in water solution or both types (p<0.01). This study indicates that sensitisation to peanut during childhood through consumption of vitamins A and D in oil-based solution seems unlikely, but its consumption may contribute to the development of a wider range of clinical symptoms due to peanut exposure.
本研究的目的是确定对花生过敏与在维生素A和D制剂中接触花生油之间是否存在关联。纳入了41名对花生进行体内或体外试验呈阳性的儿童。21名儿童食用了油溶液中的维生素A和D，14名食用了水溶液中的维生素A和D，6名同时食用了两种类型。获取了精炼和未精炼的花生油，并制备了皮肤点刺试验提取物。没有儿童对精炼花生提取物的皮肤点刺试验呈阳性反应。相比之下，15名儿童对未精炼提取物的皮肤点刺试验呈阳性。接受油基或水基配方维生素A和D的儿童中，对花生接触有临床反应的儿童数量没有显著差异。然而，对花生有临床过敏且仅食用花生油中维生素A和D的儿童，与食用水溶液或两种类型维生素的临床过敏儿童相比，食用花生后出现的不同过敏症状更多（p<0.01）。这项研究表明，儿童期通过食用油基溶液中的维生素A和D而致敏花生的可能性似乎不大，但食用这种维生素可能会导致因接触花生而出现更广泛的临床症状。
