Tanji C, Yorioka N, Kanahara K, Naito T, Oda H, Ishikawa K, Taguchi T
Department of Internal Medicine, Kure National Hospital.
Intern Med. 1999 Jun;38(6):491-4. doi: 10.2169/internalmedicine.38.491.
A 21-year-old man was admitted to Kure National Hospital with nephrotic syndrome in September 1996. He had suffered from an intractable pruritic skin rash and recurrent subcutaneous abscesses caused by the hyperimmunoglobulin E syndrome since the age of 18 months. Renal biopsy gave a diagnosis of membranoproliferative glomerulonephritis. Steroid therapy decreased urinary protein loss and hypoproteinemia, and his pruritic skin rash was improved. Patients with hyperimmunoglobulin E syndrome have a defective immune response, especially to Staphylococcus aureus infection. Continuous antigen stimulation may have caused this patient's renal histological damage as in immune complex glomerulonephritis.
1996年9月，一名21岁男性因肾病综合征入住吴市国立医院。自18个月大以来，他一直患有由高免疫球蛋白E综合征引起的顽固性瘙痒性皮疹和复发性皮下脓肿。肾活检诊断为膜增生性肾小球肾炎。类固醇治疗减少了尿蛋白丢失和低蛋白血症，他的瘙痒性皮疹也有所改善。高免疫球蛋白E综合征患者存在免疫反应缺陷，尤其是对金黄色葡萄球菌感染的免疫反应。持续的抗原刺激可能像在免疫复合物性肾小球肾炎中一样，导致了该患者的肾脏组织学损伤。
