蛋白质-蛋白质复合物中低分辨率识别的系统研究。
A systematic study of low-resolution recognition in protein--protein complexes.
作者信息
Vakser I A, Matar O G, Lam C F
机构信息
Department of Cell and Molecular Pharmacology, Medical University of South Carolina, 171 Ashley Avenue, Charleston, SC 29425, USA.
出版信息
Proc Natl Acad Sci U S A. 1999 Jul 20;96(15):8477-82. doi: 10.1073/pnas.96.15.8477.
Abstract
A comprehensive nonredundant database of 475 cocrystallized protein-protein complexes was used to study low-resolution recognition, which was reported in earlier docking experiments with a small number of proteins. The docking program GRAMM was used to delete the atom-size structural details and systematically dock the resulting molecular images. The results reveal the existence of the low-resolution recognition in 52% of all complexes in the database and in 76% of the 113 complexes with an interface area >4,000 A(2). Limitations of the docking and analysis tools used in this study suggest that the actual number of complexes with the low-resolution recognition is higher. However, the results already prove the existence of the low-resolution recognition on a broad scale.
摘要
一个包含475个共结晶蛋白质-蛋白质复合物的全面非冗余数据库被用于研究低分辨率识别，这在早期对少量蛋白质的对接实验中已有报道。对接程序GRAMM被用于删除原子大小的结构细节，并系统地对接所得的分子图像。结果显示，数据库中所有复合物的52%以及界面面积>4000 Ų的113个复合物中的76%存在低分辨率识别。本研究中使用的对接和分析工具的局限性表明，具有低分辨率识别的复合物的实际数量更高。然而，结果已经证明了低分辨率识别在广泛范围内的存在。
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