Sternberg M J, Gabb H A, Jackson R M
Biomolecular Modelling Laboratory, Imperial Cancer Research Fund, London, UK.
Curr Opin Struct Biol. 1998 Apr;8(2):250-6. doi: 10.1016/s0959-440x(98)80047-x.
Recent developments in algorithms to predict the docking of two proteins have considered both the initial rigid-body global search and subsequent screening and refinement. The result of two blind trials of protein docking are encouraging--for complexes that are not too large and do not undergo sizeable conformational change upon association, the algorithms are now able to suggest reasonably accurate models.
预测两种蛋白质对接的算法的最新进展同时考虑了初始刚体全局搜索以及后续的筛选和优化。两次蛋白质对接盲测的结果令人鼓舞——对于那些不是太大且在结合时不会发生显著构象变化的复合物，这些算法现在能够给出相当准确的模型。
