Meister P, Babaryka I
Institut für Pathologie, Städt. Krankenhaus München Bogenhausen.
Pathologe. 1999 May;20(3):183-8. doi: 10.1007/s002920050342.
This is a case of a 46-years-old male patient with a long-standing history of lower abdominal complaints. A 6-cm measuring tumor was detected by CT and subsequently surgically removed. Classification of this tumor and prognosis was problematic in frozen section and paraffin-embedded material, including immunohistochemical studies. The immunohistochemical findings were compatible with myofibroblastic differentiation of tumor cells. The histologic pattern resembled a "hyalinizing spindle cell tumor with giant rosettes" as recently published. Even if there were certain discrepancies in the immunohistochemical findings in our case, we also recommended treating this tumor as a low-grade sarcoma. The malignancy was also supported by marked proliferative activity demonstrated by MIB 1/KI 67 expression in numerous tumor cells. Finally, it has not yet been determined whether the hyalinizing spindle cell tumor is a pattern associated with a certain cellular differentiation or a pattern common to several mesenchymal tumor types.
这是一名46岁男性患者的病例，其下腹部不适病史较长。通过CT检测到一个6厘米大小的肿瘤，随后进行了手术切除。在冰冻切片和石蜡包埋材料中，包括免疫组织化学研究，该肿瘤的分类和预后存在问题。免疫组织化学结果与肿瘤细胞的肌成纤维细胞分化相符。组织学模式类似于最近发表的“伴有巨大玫瑰花结的透明变性梭形细胞瘤”。即使在我们的病例中免疫组织化学结果存在某些差异，我们仍建议将此肿瘤视为低级别肉瘤。肿瘤细胞中MIB 1/KI 67表达所显示的显著增殖活性也支持了其恶性特征。最后，透明变性梭形细胞瘤是与特定细胞分化相关的模式还是几种间充质肿瘤类型共有的模式，尚未确定。
