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挥鞭样损伤下颈椎椎体和小关节的运动学

Cervical spine vertebral and facet joint kinematics under whiplash.

作者信息

Yoganandan N, Pintar F A, Klienberger M

机构信息

Department of Neurosurgery, Medical College of Wisconsin, Milwaukee, USA.

出版信息

J Biomech Eng. 1998 Apr;120(2):305-7. doi: 10.1115/1.2798318.

DOI:10.1115/1.2798318
PMID:10412396
Abstract

Whiplash injuries sustained during a rear-end automobile collision have significant societal impact. The scientific literature on whiplash loading is both diverse and confusing. Definitive studies are lacking to describe the local mechanisms of injury that induce either acute or chronic pain symptoms. A methodology has been presented to quantify the kinematics of the cervical spine components by inducing controlled whiplash-type forces to intact human head-neck complexes. The localized facet joint kinematics and the overall segmental motions of the cervical spine are presented. It is anticipated that the use of this methodology will assist in a better delineation of the localized mechanisms of injury leading to whiplash pain.

摘要

在汽车追尾碰撞中遭受的挥鞭样损伤具有重大的社会影响。关于挥鞭样损伤负荷的科学文献既多样又令人困惑。缺乏确定性研究来描述导致急性或慢性疼痛症状的局部损伤机制。已经提出了一种方法,通过对完整的人体头颈部复合体施加可控的挥鞭样力来量化颈椎各组成部分的运动学。给出了局部小关节运动学和颈椎的整体节段运动。预计使用这种方法将有助于更好地描述导致挥鞭样疼痛的局部损伤机制。

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Cervical spine vertebral and facet joint kinematics under whiplash.挥鞭样损伤下颈椎椎体和小关节的运动学
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Whiplash-like facet joint loading initiates glutamatergic responses in the DRG and spinal cord associated with behavioral hypersensitivity.颈源性类似于鞭打的关节突关节负荷会在与行为过敏相关的背根神经节和脊髓中引发谷氨酸能反应。
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Activating transcription factor 4, a mediator of the integrated stress response, is increased in the dorsal root ganglia following painful facet joint distraction.
激活转录因子 4 是整合应激反应的中介,在疼痛的小关节分离后,其在背根神经节中增加。
Neuroscience. 2011 Oct 13;193:377-86. doi: 10.1016/j.neuroscience.2011.07.059. Epub 2011 Jul 28.
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Neuronal hyperexcitability in the dorsal horn after painful facet joint injury.疼痛性小关节损伤后背角神经元兴奋性增加。
Pain. 2010 Nov;151(2):414-421. doi: 10.1016/j.pain.2010.07.034. Epub 2010 Aug 23.
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Simulated whiplash modulates expression of the glutamatergic system in the spinal cord suggesting spinal plasticity is associated with painful dynamic cervical facet loading.模拟挥鞭伤可调节脊髓中谷氨酸能系统的表达,表明脊髓可塑性与疼痛性动态颈椎小关节负荷有关。
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