Morgan E H
Q J Exp Physiol Cogn Med Sci. 1975 Jul;60(3):233-47. doi: 10.1113/expphysiol.1975.sp002314.
The concentrations of 59Fe and of radioiodinated transferrin and albumin were measured in the blood, liver, spleen, bone marrow and ova at different times after the injection of transferrin-bound 59Fe and the labelled proteins into non-laying, laying and oestrogen treated chickens. In the egg-laying and oestrogen-treated birds the 59Fe of the plasma was rapidly transferred from transferrin to another component with the properties of th phosphoprotein, phosvitin. Radioactive iron, and labelled transferrin and albumin to a lesser extent, entered the ova only while they were in the ovary. Relatively more labelled transferrin than albumin was found in all the tissues studied except in the ova, in which the two labelled proteins were present in the same relative concentration as in the plasma. It is concluded that, during egg laying and after oestrogen treatment, plasma iron bound to transferrin is taken up by the liver, incorporated into phosvitin and is then secreted into the plasma leading to elevation of the plasma iron concentration and transfer of iron to the ova.
在向未产蛋、产蛋及经雌激素处理的鸡注射与转铁蛋白结合的⁵⁹Fe以及标记蛋白后，于不同时间测定血液、肝脏、脾脏、骨髓和卵中⁵⁹Fe、放射性碘化转铁蛋白及白蛋白的浓度。在产蛋和经雌激素处理的禽类中，血浆中的⁵⁹Fe迅速从转铁蛋白转移至具有磷蛋白、卵黄高磷蛋白特性的另一成分。放射性铁以及标记的转铁蛋白和白蛋白（程度较轻）仅在卵处于卵巢时进入卵中。在所研究的所有组织中，除卵外，发现标记的转铁蛋白相对白蛋白更多，而在卵中，两种标记蛋白的相对浓度与血浆中的相同。得出的结论是，在产蛋期间及雌激素处理后，与转铁蛋白结合的血浆铁被肝脏摄取，掺入卵黄高磷蛋白，然后分泌至血浆，导致血浆铁浓度升高并将铁转移至卵中。
