Hartnagel R E, Phillips B M, Kraus P J, Kowalski R L, Fonseca E H
Toxicology. 1975 May;4(2):215-22. doi: 10.1016/0300-483x(75)90101-8.
The subchronic toxicity of the trans isomer of N-(1,3,4,6,7-hexahydro-11bH-benzo[a] quinolizin-2-yl) propionanilide hydrochloride (TR2379), a new antihypertensive agent, was studied in rats and dogs. TR2379 was well tolerated for 13 weeks at daily p.o. doses up to 200 mg/kg in the rat and 70 mg/kg in the dog. However, severe toxic manifestations, including death, were elicited in the rat at 820 mg/kg and in the dog at 160 mg/kg. Toxicity in both species was characterized by a reduction in body weight gain and an increase in the weight of several organs, (liver, heart, kidneys, adrenals, and thyroids). Serum alkaline phosphatase, which was not assayed in the rat, was markedly increased in the dog. Microscopic examination of the various tissues revealed no evidence of organ pathology in either species.
新型抗高血压药物N-(1,3,4,6,7-六氢-11bH-苯并[a]喹嗪-2-基)丙酰苯胺盐酸盐（TR2379）反式异构体的亚慢性毒性在大鼠和犬中进行了研究。TR2379在大鼠中经口给予高达200mg/kg、在犬中给予高达70mg/kg的剂量时，13周内耐受性良好。然而，在大鼠中给予820mg/kg、在犬中给予160mg/kg时引发了严重的毒性表现，包括死亡。两个物种的毒性特征均为体重增加减少以及多个器官（肝脏、心脏、肾脏、肾上腺和甲状腺）重量增加。大鼠未检测血清碱性磷酸酶，犬的血清碱性磷酸酶显著升高。对各种组织的显微镜检查未发现两个物种中有器官病理学证据。
