Zelles T, Boros I, Varga G
Department of Oral Biology, Faculty of Dentistry, Semmelweis University of Medicine, Budapest, Hungary.
Arch Oral Biol. 1999 May;44 Suppl 1:S67-71.
Cell shape in salivary glands is affected by mechanical forces. In the acini and ducts cell shape is modified by the contractions of the myoepithelial cells in both the secretory and ductal portions of the glands. At the organ level shape changes are due to muscle contraction during mastication, food intake and speech. All these factors may cause some degree of stretching of salivary cell membranes. Recent studies suggest that physical forces influence signal transduction, gene expression, secretory function, cell differentiation and proliferation. Here we overview membrane stretch-activated cellular events. Evidence from a variety of tissues suggests that mechanical forces may alter the properties of acinar cells leading to cytoskeletal reorganisation, changes in ion fluxes, modulation of secretory activity and subsequent release of transmitters such as ATP. Transmitters released from acinar cells may modulate the secretory activity of salivary tissue, and interact with classical regulatory pathways.
唾液腺中的细胞形态受机械力影响。在腺泡和导管中，腺泡细胞和导管细胞的形态会因腺体内分泌部和导管部肌上皮细胞的收缩而发生改变。在器官层面，形态变化是由于咀嚼、食物摄入和说话时肌肉收缩所致。所有这些因素都可能导致唾液细胞膜出现一定程度的拉伸。最近的研究表明，物理力会影响信号转导、基因表达、分泌功能、细胞分化和增殖。在此，我们概述膜拉伸激活的细胞事件。来自多种组织的证据表明，机械力可能改变腺泡细胞的特性，导致细胞骨架重组、离子通量变化、分泌活性调节以及随后诸如ATP等递质的释放。腺泡细胞释放的递质可能调节唾液组织的分泌活性，并与经典调节途径相互作用。
