Domino E F, Ni L, Zhang H
Department of Pharmacology, University of Michigan, Ann Arbor, Michigan, 48109-0632, USA.
Exp Neurol. 1999 Aug;158(2):414-21. doi: 10.1006/exnr.1999.7106.
Nicotine, the soluble methyl ester of L-DOPA, and the D(2) agonist N-0923 were given alone and in combination im to five hemiparkinsonian monkeys. Daily nicotine in doses of 32-320 micrograms/kg for 6 days each, surprisingly, had slight effects on motor activity. When combined with N-0923, nicotine did not further enhance its effects. However, L-DOPA methyl ester plus nicotine produced greater contraversive circling than L-DOPA methyl ester plus 0.9% NaCl. Similar effects were obtained on significant motor movements of both the affected (contralateral) and normal (ipsilateral) arm and hand. The results indicate that nicotine is synergistic with l-DOPA methyl ester, but not with the postsynaptic D(2) agonist N-0923.
将尼古丁（L-多巴的可溶性甲酯）、D(2)激动剂N-0923单独及联合腹腔注射给五只偏侧帕金森病猴。令人惊讶的是，每天给予剂量为32 - 320微克/千克的尼古丁，连续6天，对运动活动仅有轻微影响。当与N-0923联合使用时，尼古丁并未进一步增强其效果。然而，L-多巴甲酯加尼古丁比L-多巴甲酯加0.9%氯化钠产生了更大的对侧旋转。在患侧（对侧）和正常（同侧）手臂及手部的显著运动方面也获得了类似效果。结果表明，尼古丁与L-多巴甲酯具有协同作用，但与突触后D(2)激动剂N-0923没有协同作用。
