海人酸诱导大鼠海马结构中诱导型环氧化酶和c-Jun磷酸化

Kainic acid-induced inducible cyclooxygenase and c-Jun phosphorylation in the rat hippocampal formation.

作者信息

Matsuoka Y, Okazaki M, Kitamura Y, Takata K, Tooyama I, Kimura H, Taniguchi T

机构信息

Department of Neurobiology, Kyoto Pharmaceutical University, Yamashina, Kyoto 607-8412, Japan.

出版信息

Brain Res. 1999 Jul 31;836(1-2):213-7. doi: 10.1016/s0006-8993(99)01633-9.

DOI:10.1016/s0006-8993(99)01633-9

PMID:10415422

Abstract

Inducible cyclooxygenase (COX-2) was transiently induced in the neurons throughout the entire hippocampus between 6 and 24 h after injection of kainic acid (KA). The induction of COX-2 correlated more closely with the induction of c-Jun than with that of c-Fos. Phosphorylated c-Jun was induced 6-12 h after in the CA3 pyramidal neurons, which undergo apoptosis. Almost all of neurons with phosphorylated c-Jun were colocalized with COX-2. These results suggest that COX-2 and c-Jun phosphorylation may participate in KA-induced neurodegeneration.

摘要

在注射海藻酸（KA）后6至24小时内，整个海马体中的神经元短暂诱导出诱导型环氧化酶（COX-2）。COX-2的诱导与c-Jun的诱导相关性比与c-Fos的诱导更密切。磷酸化的c-Jun在经历凋亡的CA3锥体神经元中于6至12小时后被诱导。几乎所有磷酸化c-Jun的神经元都与COX-2共定位。这些结果表明，COX-2和c-Jun磷酸化可能参与KA诱导的神经退行性变。