Frazier M L
Department of Epidemiology, University of Texas M.D. Anderson Cancer Center, Houston 77030-4095, USA.
Ann N Y Acad Sci. 1999 Jun 30;880:1-4. doi: 10.1111/j.1749-6632.1999.tb09504.x.
Both acinar and duct cell-specific gene products are expressed by pancreatic adenocarcinoma. In order to begin to understand the mechanisms by which genes of both cell types are expressed in pancreatic adenocarcinoma, an understanding of the underlying transcription factors is important. PDX1 plays an important role in the development of the pancreas and is also expressed in the adult pancreas; it is known to be involved in the regulation of expression of both acinar and islet cell-specific gene products. We have examined pancreatic adenocarcinoma cell lines and have determined that they also express PDX1, making it a candidate transcription factor for the abnormal regulation of these acinar and duc cell gene products.
胰腺腺癌可表达腺泡细胞和导管细胞特异性基因产物。为了初步了解这两种细胞类型的基因在胰腺腺癌中表达的机制，了解潜在的转录因子很重要。PDX1在胰腺发育中起重要作用，在成年胰腺中也有表达；已知它参与腺泡细胞和胰岛细胞特异性基因产物表达的调控。我们检测了胰腺腺癌细胞系，确定它们也表达PDX1，这使其成为这些腺泡细胞和导管细胞基因产物异常调控的候选转录因子。
