Ghaneh P, Neoptolemos J P
Department of Surgery, Royal Liverpool University Hospital, UK.
Ann N Y Acad Sci. 1999 Jun 30;880:308-18. doi: 10.1111/j.1749-6632.1999.tb09534.x.
Pancreatic exocrine insufficiency can follow major pancreatic resection and result in the malabsorption of fat, causing symptoms of steatorrhea, abdominal pain and weight loss. The extent of malabsorption will depend on the original disease process and the type and extent of surgical resection. The steatorrhea can be severe and difficult to control, and patients may require high doses of pancreatic enzyme supplements. There have been few studies that have looked at the treatment of steatorrhea postpancreatectomy, and very few randomized studies. Results of the latter have demonstrated that after treatment with oral pancreatic supplements over a third of postpancreatectomy patients still have significant levels of steatorrhea. These results show that even using the best available agents the complete elimination of steatorrhea following major pancreatic resection is not possible at the present time. This indicates a need for further effective therapies.
胰腺外分泌功能不全可继发于胰腺大部切除术后，导致脂肪吸收不良，引起脂肪泻、腹痛和体重减轻等症状。吸收不良的程度取决于原发病进程以及手术切除的类型和范围。脂肪泻可能很严重且难以控制，患者可能需要高剂量的胰酶补充剂。很少有研究关注胰腺切除术后脂肪泻的治疗，随机研究更是少之又少。后者的结果表明，口服胰酶补充剂治疗后，超过三分之一的胰腺切除术后患者仍有显著的脂肪泻水平。这些结果表明，即使使用现有最佳药物，目前也无法在胰腺大部切除术后完全消除脂肪泻。这表明需要进一步的有效治疗方法。
