Halaris A, Zhu H, Feng Y, Piletz J E
Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson 39216-4505, USA.
Ann N Y Acad Sci. 1999 Jun 21;881:445-51. doi: 10.1111/j.1749-6632.1999.tb09392.x.
Plasma agmatine concentrations are elevated significantly in depressed patients compared to healthy controls. Treatment with the antidepressant bupropion normalized plasma agmatine levels. Correlational evidence is presented that a change in plasma agmatine levels may lead to similar changes in platelet I1 imidazoline receptors.
与健康对照组相比，抑郁症患者血浆中胍丁胺浓度显著升高。使用抗抑郁药安非他酮治疗可使血浆胍丁胺水平恢复正常。有相关证据表明，血浆胍丁胺水平的变化可能导致血小板I1咪唑啉受体发生类似变化。
