Munkholm H, Hansen H H, Rasmussen K
Dept. of Cardiology, Aalborg Hospital, Denmark.
Biofactors. 1999;9(2-4):285-9. doi: 10.1002/biof.5520090225.
Several noninvasive studies have shown the effect on heart failure of treatment with coenzyme Q10. In order to confirm this by invasive methods we studied 22 patients with mean left ventricular (LV) ejection fraction 26%, mean LV internal diameter 71 mm and in NYHA class 2-3. The patients received coenzyme Q10 100 mg twice daily or placebo for 12 weeks in a randomized double-blinded placebo controlled investigation. Before and after the treatment period, a right heart catheterisation was done including a 3 minute exercise test. The stroke index at rest and work improved significantly, the pulmonary artery pressure at rest and work decreased (significantly at rest), and the pulmonary capillary wedge pressure at rest and work decreased (significantly at 1 min work). These results suggest improvement in LV performance. Patients with congestive heart failure may thus benefit from adjunctive treatment with coenzyme Q10.
多项非侵入性研究已表明辅酶Q10治疗对心力衰竭的影响。为了通过侵入性方法证实这一点，我们研究了22例患者，其平均左心室（LV）射血分数为26%，平均左心室内径为71mm，纽约心脏协会（NYHA）心功能分级为2-3级。在一项随机双盲安慰剂对照研究中，患者接受每日两次100mg辅酶Q10或安慰剂治疗12周。在治疗期前后，进行了右心导管检查，包括3分钟运动试验。静息和运动时的每搏指数显著改善，静息和运动时的肺动脉压降低（静息时显著降低），静息和运动时的肺毛细血管楔压降低（运动1分钟时显著降低）。这些结果提示左心室功能有所改善。因此，充血性心力衰竭患者可能从辅酶Q10辅助治疗中获益。
