Herrmann W P
MMW Munch Med Wochenschr. 1979 Jan 26;121(4):137-40.
Classical topical therapy has been largely displaced by the development of up-to-date drugs and advances in the galenic field. Serious objections have even been leveled against some older drugs and others are no longer current in spite of their good efficacy (e.g. dyes) because less discriminatory drugs can be substituted for them. The fundamental principles of classical topical therapy are still as valid as ever (inherent action of the base). However, many of the active principles of the prechemotherapeutic era have meanwhile been superseded as for example boric acid, mercury, desquamative pastes, sulfur among others. In contrast to this, topical applications such as dithranol, salicylic acid, coal tar and a few others still belong to the permanent stock of dermatological topical therapy.
随着现代药物的发展和药剂学领域的进步,经典的局部治疗方法已在很大程度上被取代。甚至有人对一些老药提出了严重的反对意见,还有一些药物尽管疗效良好(如染料),但由于有了更具针对性的药物可以替代它们,因而不再使用。经典局部治疗的基本原则仍然一如既往地有效(基质的固有作用)。然而,化疗前时代的许多活性成分,如硼酸、汞、脱皮糊剂、硫磺等,与此同时已被取代。与此形成对比的是,诸如地蒽酚、水杨酸、煤焦油等局部用药,仍然是皮肤科局部治疗的常用药物。