Kawata T, Tokimasa C, Nowroozi N, Fujita T, Kaku M, Kawasoko S, Sugiyama H, Ozawa S, Zernik J H, Tanne K
Department of Orthodontics, Hiroshima University Dental School, Japan.
J Craniofac Genet Dev Biol. 1999 Apr-Jun;19(2):113-7.
Osteopetrosis is an inherited metabolic disease characterized by an excessive accumulation of bone. This is associated with an osteoclast deficiency. Osteopetrosis is always accompanied by the failure and/or delay of tooth eruption. The present study was conducted to examine in detail the morphological and histological changes of growth of the third molars in the osteopetrosis (op/op) mouse. At the age of 10 days, normal and op/op mice showed no detectable difference in the shape of the third molar follicles. However, the third molars in the op/op mouse became obscured by the proliferation of neighboring bone trabeculae. Moreover, no tartrate-resistant acid phosphatase-positive cells were detected on the bone surfaces of 10-day-old op/op mice. Ankylosis between the root dentin and proliferating bone trabeculae was a common feature in the 20- and 30-day-old op/op mice. The third molars erupted into the oral cavity before the age of 30 days in normal mice, and the crowns, roots, and periodontal ligaments appeared well developed. Throughout the experiment, it seemed that the primary cause of the microdontia and ankylosis of the developing root in the mutant mouse was a deficiency of osteoclasts, with attendant lack of bone remodeling.
骨质石化症是一种遗传性代谢疾病，其特征是骨骼过度堆积。这与破骨细胞缺乏有关。骨质石化症总是伴随着牙齿萌出失败和/或延迟。本研究旨在详细检查骨质石化症（op/op）小鼠第三磨牙生长的形态学和组织学变化。在10日龄时，正常小鼠和op/op小鼠的第三磨牙滤泡形状没有可检测到的差异。然而，op/op小鼠的第三磨牙被邻近骨小梁的增殖所遮盖。此外，在10日龄op/op小鼠的骨表面未检测到抗酒石酸酸性磷酸酶阳性细胞。在20日龄和30日龄的op/op小鼠中，根牙本质与增殖的骨小梁之间的骨粘连是一个常见特征。正常小鼠的第三磨牙在30日龄前萌出到口腔中，牙冠、牙根和牙周韧带看起来发育良好。在整个实验过程中，似乎突变小鼠中发育牙根的小牙症和骨粘连的主要原因是破骨细胞缺乏，随之而来的是骨重塑不足。
